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Commentary by Derek Lowe at Science Translational Medicine on Small Molecule Clinical Data

Here is a blog in Science Translational Medicine that looks at available evidence for the three main antiviral treatment regimens being tried, including Remdisivir, HCQ/CQ, and lopinavir/ritanovir that discusses the terminated trials of Rem, the negative randomized trial of HCQ, an attempt to find relevant controls for the poorly constructed French HCQ study that generated the initial hype, and the two negative studies of lop/rit.

Frustrating to not see more positive results as early studies and some interim data trickle in — there are lots of ongoing studies of these drugs in different settings and with different endpoints so data will continue to come in and if any of these treatments work for a setting they will have a chance to show it.

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